Formulation and psychopharmacological evaluation of surfactant modified liposome for parkinsonism disease

摘要

A lipid based drug delivery was designed for the treatment parkinsonism diseases by delivering neurotransmitter – dopamine directly in the brain. Surfactants – span 20 (S20), span 40 (S40), span 80 (S80) and span 80 - tween 80 combinatio n (ST80) were used to prepare the carrier liposomes. Psycopharmacological studies were performed in wistar rats towards evaluating reduction of parkinsonism's extrapyramidal side effects using actophotometer and rotorod. It was found t hat ST80 formulation be the best in arresting the effect of haloperidol induced parkinsonism than the other formulation. In conclusion, administration of dopamine in ST80 modified liposomes could have considerable therapeutic effects making it to be an ideal carrier in ferrying the drug of choice direct in to the brain and thus proving a good candidate for parkinsonism treatment