Comparison of Colposcopic Biopsy Results of Patients Who have Cytomorphological Normal but HPV 16-18 or Other High-Risk HPV Subtypes Positive

摘要

Objective: Current guidelines suggest annual co-test follow-up in non-16/18 high-risk HPV positive patients withoutabnormal cytologic findings. Considering the relatively high false-negative rates of cervical cytology, a follow-up periodof one year might constitute an additional risk for development of cervical malignancies in these patients. The currentstudy aims to evaluate colposcopic biopsy results of cytologically normal patients detected to carry high risk HPV byscreening tests. Materials and Methods: A total of 160 patients with normal cervical cytology and high-risk HPVsubtypes who underwent colposcopic examination were included in the study. Patients were divided into two groupsaccording to their HPV results: HPV 16-18 and other types (non-16/18 high-risk subtypes). ECC, cervical biopsy, LEEP/conization results were analyzed for both groups. Histopathological results of the groups were compared in terms of≤LSIL, HSIL and cervical cancer rates. Results: Cervical biopsy results in the “16-18” group were assessed as HSILin 40 (48.2%) patients, LSIL in 6 patients (7.2%) and normal in 37 (44.6%) patients. ECC results revealed HSIL in9 (10.8%) patients and LSIL in 1 (1.2%) patient. Nineteen out of 42 patients who underwent LEEP/conization hadHSIL (surgical margin positivity was reported in 4 cases), while 3 patients had LSIL. None of the cases had cervicalcarcinoma. Conclusion: The present study detected that 15.6% of women infected with non-16/18 high-risk HPVsubgroups developed ≥HSIL lesions. Although this rate seems lower than HPV 16-18 group, it is still too high to beoverlooked. In conclusion, we suggest further clinical trials with larger number of patients to be conducted on this topic.