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首页> 外文期刊>Asian Pacific Journal of Cancer Prevention >Evaluation Expression of Microrna-93 and Integrin Β8 in Different Types of Glioma Tumors
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Evaluation Expression of Microrna-93 and Integrin Β8 in Different Types of Glioma Tumors

机译:Microrna-93和整合素Β8在不同类型胶质瘤肿瘤中的表达评估

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MicroRNAs (miRNAs), are a type of small non-coding RNAs, that induce mRNA degradation or repress translation by binding to the 3′-untranslated region (UTR) of its target mRNA. Some specific miRNAs, e.g. miR-93, have been discovered to be involved in pathological procedures by targeting some oncogenes or tumor suppressors in glioma. In the present study, real-time RT-PCR data was indicated the expression pattern and prognostic value of miR-93 in patients with types of Glioma.MiR-93 expression was significantly decreased in tumor tissue compared with normal group brain tissues (P<0.001). Low miR-93 expression was significantly correlated with progressive tumor grade (P=0.02).Moreover, multivariate analysis showed that miR-93 decreased expression (HR, 4.3; 95% CI, 0.8–17.2, P=0.02), advanced tumor grade (HR, 3.1; 95% CI, 0.2–13.9, P=0.04), for integrinβ8, level expression was inverse. Our data was shown that the down regulation of miR-93 was significantly correlated with unfavorable pathological features in patients with Glioma .Suggesting that decreased expression of miR-93can be used as a novel prognostic factor for this disease.
机译:MicroRNA(miRNA)是一类小的非编码RNA,可通过与其目标mRNA的3'-非翻译区(UTR)结合而诱导mRNA降解或抑制翻译。一些特定的miRNA,例如通过靶向神经胶质瘤中的某些癌基因或肿瘤抑制因子,发现miR-93参与了病理过程。在本研究中,实时RT-PCR数据显示了miR-93在胶质瘤类型患者中的表达模式和预后价值。与正常组脑组织相比,miR-93在肿瘤组织中的表达明显降低(P < 0.001)。 miR-93的低表达与进行性肿瘤分级显着相关(P = 0.02)。此外,多因素分析显示,miR-93的表达降低(HR,4.3; 95%CI,0.8-17.2,P = 0.02),晚期肿瘤(HR,3.1; 95%CI,0.2-13.9,P = 0.04),对于整联蛋白β8,水平表达是相反的。我们的数据表明,miR-93的下调与脑胶质瘤患者的不良病理特征显着相关。建议将miR-93的表达降低作为该病的新预后因素。

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