CAR T CELLS TARGETING THE INTEGRIN ALPHAv BETA3 EXHIBIT ROBUST ANTI-TUMOR RESPONSES AGAINST GLIOMAS AND OTHER SOLID TUMOR MALIGNANCIES

摘要

Methods and compositions for treating cancer, including brain cancers such as diffuse intrinsic pontine glioma (DIPG) and glioblastoma (GBM), breast cancers, melanomas, cervical cancers, bladder cancers, lung cancers, neuroblastomas, and rhabdomyosarcomas (RMS), are described. Also described are methods of preparing cells comprising chimeric antigen receptors (CARs), such as CAR T cells, that target integrin alphav beta3 (ανβ3).