WOUND HEALING ACTIVITY OF BARRINGTONIA ACUTANGULA FRUIT EXTRACT

摘要

Objective: To evaluate wound healing activity of methanolic extract of Barringtonia acutangula fruits (MEBA). Methods: Both excision and incision models were used in rats. In the excision wound model, the wound area of each animal was measured on days 0, 2, 4, 6, 8, 10, 12, and 14 after inflicting the wound. Wound contraction (WC) was calculated as a percentage change in the initial wound size. The histopathology study of the skin (newly formed on the wounds) was carried out on the 12 post wounding day. In the incision wound model, the tensile strength was measured using tensiometer on the 14 th post wounding day. th Results: MEBA at 20% w/w showed highly significant wound healing activity (p<0.01) as compared to control. The percentage of WC on the 14 day by MEBA at 5%, 10%, and 20% w/w were found to be 93.86%, 93.86%, and 96.43%, respectively. There is increased the number of fibroblasts, increased collagen tissue and complete epithelialization in the case of MEBA ointment 20% w/w. Conclusion: MEBA fruit (ointment) showed significant wound healing activity in both excised wound model (20% w/w) and incision wound model (10% w/w) rats.