QUINIC ACID AS A POTENT DRUG CANDIDATE FOR PROSTATE CANCER – A COMPARATIVE PHARMACOKINETIC APPROACH

摘要

Objective: Phytotherapy is growing importance with the emergence of deadly diseases. Prostate cancer is one such disease which is the most prevalent cancer afflicting men. Therapeutic application of plant is better understood with the pharmacological investigation of its phytoconstituents. Quinic acid is a prominent bioconstituent of flowers of Moringa oleifera Lam, a traditional plant of high nutritional and medicinal values. The present study analyzes the pharmacokinetic properties of this phytocomponent for its therapeutic application in prostate cancer.Methods: In silico tools were used to screen the physicochemical, Lipinski-type and drug properties of Quinic acid from the other compounds used for comparison. The M. oleifera flower compound, Quinic acid and the standard therapeutic Curcumin were the ultimate compounds selected for further studies on their Adsorption-Distribution-Metabolism-Excretion (ADME) characteristics and toxicity parameters.Results: The overall pharmacokinetics results indicated that Quinic acid had more number of advantages over Curcumin and the other compounds studied. Quinic acid possessed greater values of drug score and drug likeness with lesser brain penetration and lesser toxicity effects.Conclusion: The study suggested that the pharmacokinetic properties of Quinic acid were more preferable to be used as a potent drug candidate to combat prostate cancer.