New quantitative estimation of benzoic acid bulk sample using calcium disodium edetate as hydrotropic solubilizing agent

摘要

In the present investigation, hydrotropic solubilization technique has been employed to solubilize the slightly water soluble topical antifungal drug, benzoic acid (by 1.0 M calcium disodium edetate solution), for its titrimetric analysis. There was more than 15 fold enhancement in aqueous solubility of benzoic acid in 1.0 M calcium disodium edetate solution as compared to the solubility in distilled water. The hydrotropic agent did not interfere in the analysis. The proposed method is new, simple, accurate and reproducible. Statistical data proved the accuracy, reproducibility and precision of the proposed method