兔颅骨缺损修复中对多孔块状β-磷酸三钙陶瓷可吸收性的定量研究

摘要

Objective:To study the absorption of porous block β-tricalcium phosphate(β-TCP) implanted in the defects of rabbit calvarium. Methods :Twenty-four rabbits were randomly divided into four groups with six in each,a round piece of bone with the diameter of 8 mm was removed on left and right sides in the calvarium of each animal. β-TCP samples were implanted in the left defects and hydroxyapatite(HA) in the right. Rabbits were sacrificed at 2,4,8,12 weeks after operation respectively, The implanted materials were quantitatively measured by "Point Counting". Results: Twelve weeks after operation, the amount of β-TCP and HA remained in the transplants were 34.54% and 49. 28% ,while the bone tissue comprised 24.43 % and 19.67 % of β-TCP and HA transplants respectively. Conclusion:Porous block β-TCP is more absorbable and more feasible for new bone tissue regeneration than HA.%目的：通过多孔块状β磷酸三钙(β-TCP)对兔颅骨缺损的修复，定量测量其在体内的吸收速度。方法：24只家兔随机分为2，4，8，12周4个时间点组，每组6只动物，分别将β-TCP及羟基磷灰石(HA)样本种植在兔左右顶骨的缺损处，于术后2，4，8，12周取材，采用"数点法"计算各组材料的剩余量。结果：12周时β-TCP组材料剩余34．54％，材料吸收了40．01％。结论：多孔块状β-TCP陶瓷作为骨代用品，不失为一种较好的材料。