PATI: Patient accessed tailored information

摘要

Aims: Villus morphogenesis is the process by which the luminal epithelium of the intestine changes from being a flat surface to having crypts andvilli. In mammalian development, villi form in proximal bowel first andsubsequently spread distally in a wave of morphogenesis. Better understanding the factors controlling the development and maintenance of villimay help guide therapies for patients suffering post-bowel resection intestinal failure. It is not known whether the propagation of villusmorphogenesis occurs as a result of a proximal–distal signaling cascade, orby intrinsic factors which trigger villus growth at predetermined timepoints. An embryonic mouse tissue culture model was used toexplore this.