p-TSA Catalysted, One-Pot Synthesis and Antimicrobial Evaluation of Some Novel Fused Dipyrazolo-1,4-Dihydropyridine Derivatives

摘要

Some novel dipyrazolo-1,4-dihydropyridine derivatives have been synthesized via one-pot, multi-component condensation of N-phenylpyrazole, aldehyde and ammonium acetate using p-TSA as catalyst. The fused dipyrazolo-1,4-dihydropyridine molecules without using expensive starting materials and the molecules are obtained in excellent yield without using any special purification technique. The synthesized compounds were screened for their in vitro antibacterial and antifungal activity against six bacterial and four fungal species. Among these 4a, 4e and 4h exhibited significant antibacterial activity against various bacterial and fungal strains.