Formulation and Evaluation of Topical Formulation of Coriander Oil With Penetration Enhancer

摘要

  ABSTRACT Acne is an inflammatory disease of sebaceous follicles of skin. The present study was conducted to formulate and evaluate the topical anti acne formulation of coriander oil with penetration enhancer. The antibacterial activity of Coriander oil against Propionibacterium acne and Staphylococcus epidermidis was investigated using disc diffusion method and minimum inhibitory concentration was determined by agar dilution method. The topical formulations were developed using menthol as the penetration enhancer and tested for physical parameters, drug content uniformity, spreadibility, extrudability and in-vitro diffusion. The results showed that coriander oil showed the MIC values of 1%v/v and 1.1%v/v against P.acne and S. epidermidis respectively. It was reveled from the results that all the formulations showed the increased zone of inhibition for both of the bacteria. The formulations with the addition of penetration enhancer showed the increased drug content as well as the invitro release which increased with increase in the concentration of menthol. The formulation  Fo11 showed the drug content (98.9%), invitro- diffusion (98.2%) and maximum stability among all the formulations. So it is the potent formulation to be further developed for treatment of acne. Keywords: acne vulgaris, antibacterial activity, coriander, penetration enhancer , in-vitro activity.