DNMT3B modulates the expression of cancer-related genes and downregulates the expression of the gene VAV3 via methylation

Irlanda Peralta-Arrieta; Daniel Hernández-Sotelo; Yaneth Castro-Coronel; Marco Antonio Leyva-Vázquez; Berenice Illades-Aguiar

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DNMT3B modulates the expression of cancer-related genes and downregulates the expression of the gene VAV3 via methylation

机译：DNMT3B通过甲基化调节癌症相关基因的表达并下调VAV3基因的表达

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Altered promoter DNA methylation is one of the most important epigenetic abnormalities in human cancer. DNMT3B,?de novo?methyltransferase, is clearly related to abnormal methylation of tumour suppressor genes, DNA repair genes and its overexpression contr

机译：启动子DNA甲基化改变是人类癌症中最重要的表观遗传异常之一。 DNMT3B是新的甲基转移酶，显然与肿瘤抑制基因，DNA修复基因及其过度表达的异常甲基化有关。

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《American Journal of Cancer Research》 |2017年第1期|共11页
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Irlanda Peralta-Arrieta; Daniel Hernández-Sotelo; Yaneth Castro-Coronel; Marco Antonio Leyva-Vázquez; Berenice Illades-Aguiar;
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中图分类肿瘤学;
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1. HIV infection of human regulatory T cells downregulates Foxp3 expression by increasing DNMT3b levels and DNA methylation in the FOXP3 gene [J] . PionM., Jaramillo-RuizD., MartínezA., AIDS . 2013,第13期

机译：HIV感染人类调节性T细胞会通过增加DNMT3b水平和FOXP3基因中的DNA甲基化来下调Foxp3表达
2. Expression of ECRG4, a novel esophageal cancer-related gene, downregulated by CpG island hypermethylation in human esophageal squamous cell carcinoma [J] . Chun-Mei Yue, Da-Jun Deng, Mei-Xia Bi, World Journal of Gastroenterology . 2003,第6期

机译：CpG岛超甲基化下调食管癌相关新基因ECRG4在食管鳞癌中的表达
3. The Dioxin Receptor Regulates the Constitutive Expression of the Vav3 Proto-Oncogene and Modulates Cell Shape and Adhesion [J] . Jose M. Carvajal-Gonzalez, Sonia Mulero-Navarro, Angel Carlos Roman, Molecular biology of the cell . 2009,第6期

机译：二恶英受体调节Vav3原癌基因的组成型表达，并调节细胞的形状和粘附。
4. Gene expression inhibition of N-Myc downregulated gene 1 (NDRG1) monitoring and facilitation via transfectional transfer of NDRG1-siRNA constructs into- in vitro-cultured human glioblastoma cells [C] . Said Harun M., Polat Buelent, Guckenberger Mathias, 2011 4th International Conference on Biomedical Engineering and Informatics . 2011

机译：通过将NDRG1-siRNA构建体转染至体外培养的人成胶质细胞瘤细胞中，N-Myc基因下调的基因1（NDRG1）的监测和促进基因表达抑制
5. Kaposi's Sarcoma associated Herpes-virus induces cellular PROX1 expression to modulate host gene expression that benefits viral infection and oncogenesis. [D] . Aguilar, Berenice. 2012

机译：卡波西氏肉瘤相关疱疹病毒诱导细胞PROX1表达，以调节宿主基因表达，从而有利于病毒感染和肿瘤发生。
6. DNMT3B modulates the expression of cancer-related genes and downregulates the expression of the gene VAV3 via methylation [O] . Irlanda Peralta-Arrieta, Daniel Hernández-Sotelo, Yaneth Castro-Coronel, 2017

机译：DNMT3B通过甲基化调节癌症相关基因的表达并下调VAV3基因的表达
7. Expression of ECRG4, a novel esophageal cancer-related gene, downregulated by CpG island hypermethylation in human esophageal squamous cell carcinoma [O] . Chun-Mei Yue 2003

机译：ECRG4，一种新型食管癌相关基因的表达，通过CPG岛高甲基化在人食管鳞状细胞癌中下调

DNMT3B modulates the expression of cancer-related genes and downregulates the expression of the gene VAV3 via methylation

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