Clinical Evaluation of Dose Dependent Adverse Drug Reactions and Possible Risk Factors in Patients with Rheumatoid Arthritis Treated with Methotrexate

摘要

ABSTRACT Methotrexate is considered as the standard drug treatment for Rheumatoid arthritis. The purpose of this study is to find out the incidence of Adverse Drug Reactions (ADR), and possible risk factors in patients of rheumatoid arthritis administering methotrexate. And to determine the possibility of any new adverse drug reaction that is not well explored in previous studies. An observational follow up study designed and conducted using Naranjo scale to identify the adverse drug reactions in rheumatoid arthritis patients administering methotrexate in KIM’s Hospital.  The objective is to identify the dose dependent adverse drug reactions in rheumatoid arthritis patients and identify possible risk factors associated adverse drug reactions of methotrexate of methotrexate. Toxic effects may occur hours, to days to weeks after methotrexate administration and or overdose, the purpose of this study is to determine the relation between the dose and the occurrence of adverse drug reaction of methotrexate. During the study period clinically relevant adverse drug reaction have been presented by the patients taking methotrexate who attended hospital for their regular checkup. For example, the most commonly reported adverse drug reaction is abnormal taste for food and other less commonly presented adverse drug reaction include diarrhea, constipation, nausea, vomiting, and alopecia. In female patient’s 20-49 age group reported adverse drug reaction like amenorrhea, dysmenorrhea. Methotrexate toxicity develops due to increased patient susceptibility during the treatment. Keywords: Rheumatoid Arthritis, Methotrexate, Adverse drug reaction (ADR), Naranjo scale.