Solid Dispersion Incorporated Microcapsules: Predictive Tools for Improve the Half Life and Dissolution Rate of Pioglitazone Hydrochloride

摘要

The present study was aimed to formulate the solid dispersion incorporated microcapsule to improve the dissolution rate and half life of pioglitazone hydrochloride. The solvent evaporation method was used to formulate the solid dispersion resulted increased dissolution rate, bioavailability and stability. Finally increase the half life of the drug by employ the orifice ionic gelation method to formulate solid dispersion incorporated muco-adhesive microcapsule. The solubility of pioglitazone hydrochloride was increase by the preparation of its solid dispersion with polyvinyl pyrrolidone K30 using solvent evaporation methods. The microcapsules of pioglitazone hydrochloride were prepared by (orifice ionic gelation method) employing sodium alginate as a cell forming polymer and using a different bio-adhesive polymers as carbopol, HPMC and sodium CMC in a various ratios of 1:1, 3:1, 6:1 & 9:1, by orifice ion gelation method. FT-IR spectra revealed no chemical incompatibility between drug and polymers. Drug-polymer interactions were investigated using differential scanning calorimetry (DSC), Powder X-Ray Diffraction (PXRD). Scanning electron microscope photographs of samples revealed that all prepared microcapsules were almost spherical in shape and have a slightly smooth surface.