Understanding the Biological Mechanism of Alopecia Areata

摘要

Alopecia Areata or AA is a condition of patchy hair loss that results from a non-scarring, autoimmune, inflammatory skin disease. Though it has known to affect both genders, studies have shown that most male suffer AA. It is a complex and poorly understood entity. Presently, the hypotheses for AA development generally focus on the collapse of immune privilege properties of the hair follicles and the nature of self-antigen presentation that result in the induction and subsequent attack of activated lymphocytes. The treatment options for AA are limited and the effectiveness of these treatments differs. Some of the recent hypothesis and studies on AA are offered for a broader understanding of the biological mechanisms of AA.