Evaluation of Some Lichen Extracts for β-Glucosidase Inhibitory as a Possible Source of Herbal Anti-diabetic Drugs

摘要

In the present study, lichen species; Herpothallon sp., Parmotrema tinctorum, Leptogium sp., Heterodermia leucomelos, Parmotrema crinitum, Ramalina sinensis, Parmotrema reticulatum and Cladonia subradiata were evaluated for their β-glucosidase inhibitory, which is linked with anti-diabetic effect. Lichens had proved to be promised source of dug discovery in many researches, but this particular aspect of enzyme inhibitory is still not studied properly, so this study was performed in order to find out new natural source of anti-diabetic drugs by inhibition of β-glucosidase enzyme. Overall, All species showed inhibition in one or all their solvents extract. Ethanol was the most suitable solvent to extract glucosidase inhibitory components. R. sinensis (91%), Leptogium sp. (87%), and H. leucomelos (85%) showed highest inhibition which was higher than standard glucosidase inhibitor; acarbose (65%). There was a linear correlation (r=0.5360) between inhibitory activity and phenolic contents. So we can emphasize that Lichen phenolic compounds can be a great natural source of β-glucosidase inhibitors.