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Applying Length-Dependent Stochastic Context-Free Grammars to RNA Secondary Structure Prediction

机译:将长度相关的随机上下文无关文法应用于RNA二级结构预测

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In order to be able to capture effects from co-transcriptional folding, we extend stochastic context-free grammars such that the probability of applying a rule can depend on the length of the subword that is eventually generated from the symbols introduced by the rule, and we show that existing algorithms for training and for determining the most probable parse tree can easily be adapted to the extended model without losses in performance. Furthermore, we show that the extended model is suited to improve the quality of predictions of RNA secondary structures. The extended model may also be applied to other fields where stochastic context-free grammars are used like natural language processing. Additionally some interesting questions in the field of formal languages arise from it.
机译:为了能够从共转录折叠中捕获效果,我们扩展了随机上下文无关文法,以使应用规则的概率可以取决于最终由规则引入的符号生成的子词的长度,并且我们表明,用于训练和确定最可能的解析树的现有算法可以轻松地适应扩展模型,而不会降低性能。此外,我们表明扩展模型适合提高RNA二级结构的预测质量。扩展模型还可以应用于其他使用随机上下文无关文法的领域,例如自然语言处理。此外,由此引起了形式语言领域的一些有趣问题。

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