p53 oncogene mutations in head and neck cancer based on the weighted Euclidean distance

摘要

In order to study?the p53 mutations?in head and neck cancer, we?explored therelationship between the different positions of the bases and the amino acids’ physical and chemical properties.?In this paper, the?Euclidean distance?(d) was defined. Furthermore, by using?improved variation coefficient method, the Euclidean named asweighted?Euclidean distance?(d*) was weighted, and then the p53 oncogene mutations in head and neck cancer was analyzed by using?d?and?d*. The method based on the?d* can judge which position of the bases had changed more obviously.When?d* was more than 1.5, the second base, as well as?the?physical and chemical properties?of amino acids, changed. In contrast, when?d* was less than 1.2, the first or the third base changed, but?the physical and chemical properties of amino acids were not changed.?The results therefore show that?the second base has the greatest influence on amino acids, the first has smaller influence, and?the third has less impact on?the physical and chemical properties of amino acids.