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Nucleic acids encoding p53 mutations which suppress p53 cancer mutations
Nucleic acids encoding p53 mutations which suppress p53 cancer mutations
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机译:编码p53突变的核酸可抑制p53癌症突变
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摘要
Intragenic suppressor mutations of common p53 mutations are able to function in cis and/or trans. These mutations are useful for identifying small molecule drugs which function in a similar fashion. In addition, the mutations themselves may be useful therapeutically, especially if they function in trans. Methods for rapidly obtaining this type of mutant employ a yeast selection system. Cells having both the negative mutation and intragenic suppressor are useful for studying the interactions of the two, in particular in determining the structure of the homotetramers and heterotetramers.
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