Chemical composition and in vitro antioxidant, cytotoxicity activities of Zingiber officinale Roscoe essential oil

摘要

This study was designed to examine thein vitroantioxidant and cytotoxicity activities ofZingiber officinaleRoscoe (ginger) rhizome essential oil. GC-MS analysis of the essential oil resulted in the identification of 7 compounds, representing 90.06% of the oil, the major constituents were described as α-zingiberene (52.35%), β-pinene (14.20%) and β-sesquiphellandrene (12.11%). The oil was subjected to screening for their possible antioxidant activity by means of 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and β-carotene bleaching test. In the DPPH test system, the concentrations providing 50% inhibition (IC50) values of free radical-scavenging activity of ginger essential oil was determined to be 0.0144% (v/v). In the β-carotene bleaching test system, we tested series concentration of samples to show the antioxidant activities of the oil, the IC50values of ginger essential oil was 0.55% (v/v). Ginger essential oil exhibited the strong cytotoxicity towards two human cancer cells at low concentration. Its IC50values on HO-8910 and Bel-7402 were 0.00643 and 0.00256% (v/v), respectively.