Therapeutic proteins administered into the intravitreal (IVT) chamber of the eye have become the treatment option of choice for several ocular disorders. The understanding of ocular and systemic pharmacokinetics (PK) as well as pharmacodynamics (PD) is still developing. Here, we present a perspective on current knowledge and knowledge gaps as well as an allometric framework to extrapolate exposure in the vitreous and systemic circulation to children focusing on relative changes in clearance.
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