In vitro Antiproliferative activity of Seagrass Halodule pinifolia (Miki) on MCF7 Human Breast Cancer Cell Line

摘要

Halodule pinifolia is one of the abundant seagrass found along the Vellar estuary. Parangipettai, Tamil nadu, India. In vitro antiproliferative test was performed by MTT (methylthiozoltetrazolium) assay method against MCF7 human breast cancer cells. The ethyl acetate fraction showed that toxicity against cancer cells whereas in normal vero cells no such changes were observed. Ethyl acetate extract of H. pinifolia recorded the maximum antiproliferative activity. Inhibitory concentration (IC50) value of the MCF7 cell line was 66.68 μg/ml. The present findings suggest the possible pharmacological applications of selected seagrass that can be used as food further investigation into the potential used of H. pinifolia as an alternative treatment for cancer.