Serum Magnesium as an Important and Independent Predictor of Acute Exacerbations of COPD Patients

摘要

Magnesium is one of the most important factors for regulation of inflammatory response as well as muscle function. A decrease in serum Mg+2 is associated with airway hyper-reactivity, impaired pulmonary function. Data suggest that low serum Mg+2 levels are associated with an increased risk of exacerbation of symptoms in COPD patients. The aim of this study was to establish efficacy of S. Magnesium levels as a predictor of acute exacerbation of COPD. The present study was conducted on 50 normal healthy controls and 150 non-tubercular Chronic Obstructive Pulmonary Disease (COPD) patients attending OPD/indoor at Pulmonary Medicine Department of L N Rathi Memorial Hohpital, Jodhpur. All the subjects were subjected to PFT assessment and Serum Magnesium was determined. Data thus obtained were compared with controls by student’s t-test. Our results show that all PFT parameters were found to be significantly low in COPD Patients as compared to controls. S. Mg levels in moderate and severe COPD Patients compared to healthy subjects were significantly low (with p-value 0.0000001). We can conclude that there is direct negative correlation between COPD and blood Mg++ levels. Our data suggest proportionate fall in Mg++ values is strongly associated with the rise in the severity of COPD. Our results also clearly indicate negative correlation between hypomagnesaemia and frequency and duration of hospitalization.