Purpose: The present study involves preparation and evaluation of diclofenac buccal-mucoadhesive microparticles for prolongation of buccal residence time.Methods: The microparticles were prepared by modified double-emulsion dehydration method (O1/W/O2) using sodium carboxymethylcellulose (CMC-Na) as mucoadhesive polymer. Calcium chloride was used as a cross-linking agent. Buccal-mucoadhesive microparticles with different drug to polymers ratios were prepared and characterized by encapsulation efficiency, particle size, DSC (Differential Scanning Calormetric), flowability, degree of swelling, surface pH, mucoadhesive property and drug release studies.Results: The best drug to polymer ratio in microparticles was 1:5 (F3) with CMC-Na. F1 microparticles showed loading efficiency 51.43% and mean particle size 1013.92 μm. The DSC showed stable character of drug in microparticles and revealed amorphous form. Microparticles had slower release than the commercial tablet (p50 min). Histopathological studies revealed no buccal mucosal damage.Conclusion: It may be concluded that drug loaded buccal-mucoadhesive microparticles are a suitable delivery system for DS.
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机译：目的：本研究涉及双氯芬酸颊黏膜黏附微粒的制备和评价，以延长颊停留时间。方法：采用羧甲基纤维素钠（CMC-Na）改良双乳液脱水法（O1 / W / O2）制备微粒作为粘膜粘附聚合物。氯化钙用作交联剂。制备了具有不同药物与聚合物比率的颊粘膜粘附微粒，并通过包封效率，粒径，DSC（差示扫描量热），流动性，溶胀度，表面pH，粘膜粘附特性和药物释放研究对其进行了表征。结果：使用CMC-Na时，微粒中的聚合物比率为1：5（F3）。 F1微粒的负载效率为51.43％，平均粒径为1013.92μm。 DSC在微粒中显示药物的稳定特性，并显示无定形形式。微粒的释放速度比市售片剂慢（50分钟）。组织病理学研究未发现颊黏膜损伤。结论：可以得出结论，载药颊黏膜粘附微粒是DS的合适递送系统。
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