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Magnetic resonance imaging findings in probable Creutzfeld-Jacob disease: comparison with electroencephalography and cerebrospinal fluid characteristics

机译:可能的克雅氏病的磁共振成像结果:与脑电图和脑脊液特征的比较

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Creutzfeld-Jacob disease (CJD) is a rare, progressive disease that has a vast clinical manifestation range. Cranial magnetic resonance imaging (MRI), electroencephalography (EEG), and measurement of 14-3-3 in cerebrospinal fluid (CSF) may offer a pragmatic approach in the diagnosis of CJD as an alternative to histopathological confirmation. To present the symptoms and signs of the CJD patients in regard to radiological and neurophysiological findings. We collected all cases with the diagnosis of probable CJD admitted to our neurology department between June 2010 and June 2014. The medical records and laboratory data, clinical features, results of MRI (including diffusion weighted images), EEG and CSF evaluations, and other laboratory data to exclude other possible diagnoses were recorded. None of the patients underwent biopsy or autopsy for histological diagnosis. Of 20 patients, 11 (55%) were men and nine (45%) were women. The mean age at disease onset was 60.0?±?9.5 years (age range, 47–80 years). All patients without exception had characteristic abnormalities in DWI and/or FLAIR on admission, about 4 months after the initial symptom. Periodic complexes on EEGs characteristic for CJD were detected only in 10 patients (50%) on admission and in 13 patients (65%) during disease course. Out of 14 patients who underwent CSF examination, 11 (78.5%) were positive for 14-3-3 protein. Although the definite diagnosis of CJD is made histopathologically, we aimed to discuss the value of magnetic resonance imaging in the diagnosis of CJD in respect to EEG findings and protein 14-3-3 levels in CSF.
机译:克雅氏病(CJD)是一种罕见的进行性疾病,具有广泛的临床表现范围。颅脑磁共振成像(MRI),脑电图(EEG)和脑脊液(CSF)中14-3-3的测量可能为诊断CJD提供了一种实用的方法,可作为组织病理学证实的替代方法。介绍有关放射和神经生理学发现的CJD患者的症状和体征。我们收集了2010年6月至2014年6月间进入神经内科的所有可能被诊断为CJD的病例。病历和实验室数据,临床特征,MRI结果(包括弥散加权图像),EEG和CSF评估以及其他实验室记录了排除其他可能诊断的数据。没有患者接受活检或尸检以进行组织学诊断。在20名患者中,男性为11名(55%),女性为9名(45%)。疾病发作的平均年龄为60.0±9.5岁(年龄范围47-80岁)。入院后约4个月,所有患者均无异常DWI和/或FLAIR异常。入院时仅在10例患者(50%)和病程中13例患者(65%)中检测到具有CJD特征的脑电图周期性复合物。在接受CSF检查的14例患者中,有11例(78.5%)的14-3-3蛋白呈阳性。尽管对CJD进行明确的诊断是从组织病理学角度进行的,但我们的目的是就脑电图的脑电图结果和蛋白14-3-3水平探讨磁共振成像在CJD诊断中的价值。

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