Purpose:The aim of this study was to design andformulationof potassium citrate effervescent tablet for reduction of calcium oxalate and urate kidney stones in patients suffering from kidney stones. Methods:In this study,13 formulations were prepared from potassium citrate and effervescent base in different concentration. The flowability of powders and granules was studied. Then effervescent tablets were prepared by direct compression, fusion and wet granulation methods. The prepared tablets were evaluated for hardness, friability, effervescent time, pH, content uniformity. To amend taste of formulations, different flavoring agents were used and then panel test was done by using Latin Square method by 30 volunteers. Results:Formulations obtained from direct compression and fusion methods had good flow but low hardness. Wet granulationimproves flowability and other physicochemical properties such as acceptable hardness, effervescence time ?ü3 minutes, pH<6, friability < 1%, water percentage < 0.5% and accurate content uniformity. In panel test,both of combination flavors; (orange -lemon) and (strawberry -raspberry) had good acceptability. Conclusion:The prep ared tablets by wet granulationmethod using PVP solution had more tablet hardness. It is a reproducible process and suitable to producegranules that are compressed into effervescenttablets due to larger agglomerates
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