The effects of tamoxifen on learning, memory and brain tissues oxidative damage in ovariectomized and na?ve female rats

摘要

Background: Regarding the modulatory effects of tamoxifen (TAM) on the actions of estrogen in the present study, the effects of TAM on learning, memory and brain tissues oxidative damage in ovariectomized (OVX) and naοve female rats was investigated. Materials and Methods: The animals were divided into: (1) Sham, (2) OVX, (3) Sham-tamoxifen (Sham-TAM) and (4) ovariectomized-tamoxifen (OVX-TAM). The animals of the Sham-TAM and OVX-TAM groups were treated by TAM (1 mg/kg; 4 weeks). Results : In Morris water maze, the escape latency in the OVX group was higher than in the Sham group ( P P 1 ) by the animals of OVX group was lower than that of Sham group ( P 1 ) compared with OVX group ( P P P P P Conclusions: These results allow us to propose that TAM enhances learning and memory of OVX rats. The possible mechanism may be due to the protective effects against brain tissues oxidative damage.