Primary paraganglioma of thyroid gland: a clinicopathologic and immunohistochemical study with review of the literature

摘要

Primary paraganglioma of the thyroid is a very rare neuroendocrine tumour. Only 24 cases have been reported in the Literature. a case of a primary paraganglioma of the thyroid is presented in order to provide a review of the Literature, an update on current knowledge and to emphasize the key diagnostic role of immunohistochemistry. a 63-year-old female presented with a 6-month history of right-sided solitary thyroid nodule. ultrasonography and fne needle aspiration biopsy were not diagnostic. The patient underwent right hemithyroidectomy. The tumour cells showed a strongly positive staining for chromogranin a, synaptophysin and neuron specifc enolase, whereas S-100 pro- tein was positive in sustentacular cells. a diagnosis of primary paraganglioma of the thyroid was made. radiotherapy for suspected local tumour persistence was planned. at 18-months follow-up, the patient is alive without evidence of recurrence. This case highlights the need to include primary paraganglioma of the thyroid in the differential diagnosis of neuroendocrine intra-thyroidal tumours. Immunohisto- chemistry is essential for diagnosis. Surgery is the treatment of choice.