Primer osteoartrit olgular?nda plazma ve sinovyal s?v? doku fakt?rü ve koagülasyon parametrelerinin incelenmesi

摘要

?zet Ama?. Dejeneratif eklem hastal?klar?nda sinovyadaki fibrin birikimi hastal???n prognozunu a??rla?t?ran sebepler aras?ndad?r. Bu ?al??mada total diz artroplastisi (TDA) ameliyat?na girecek olan hasta grubunun sinovya ve kanlar?ndaki doku fakt?rü (DF) ve di?er koagülasyon fakt?rlerinin de?i?imlerinin incelenmesi ama?land?. Y?ntem. Bu ?al??mada kontrol grubuna k?yasla (n=20), hasta grubunun (n=20) sinovya ve plazmalar?nda DF miktar? ve ilgili olan di?er ekstrensek koagülasyon fakt?rleri incelendi. Plazma ve sinovyan?n DF düzeyleri ELISA y?ntemi ile, di?er koagülasyon fakt?rleri ve protrombin zaman? ticari kitlerle, fibrinojen otomatik koagülometrede ve C-reaktif protein nefelometrik y?ntemle ?l?üldü. Bulgular. Hasta grubunun DF seviyeleri hem sinovyada, hem de plazmada anlaml? olarak yükselmi?tir (p<0,001 ve p<0,05). Bununla birlikte di?er ekstrensek sistem fakt?rleri de olgular?n sinovyalar?nda kontrol grubuna g?re artm??t?r. Sonu?lar. TDA ameliyat?na girecek olan olgular?n sinovya ve plazmalar?nda artm?? DF’ den kaynakland???n? dü?ündü?ümüz yüksek fibrin miktar? hasta grubunda koagülasyon ve enflamasyonu tetikleyebilece?inden hastal?k sürecini olumsuz y?nde etkileyebilir. Bu ?al??mada g?zlemlenen DF ve di?er baz? ekstrensek sistem fakt?rlerinin plazmada ve ?zellikle sinovyadaki art??lar? koagülasyonu aktif hale getirerek bu hasta grubundaki tromboz riskini artt?rd???n? dü?ünmekteyiz. Anahtar s?zcükler: Doku fakt?rü, enflamasyon, koagülasyon Abstract Aim. Since in degenerative joint diseases accumulation of fibrin is one of the reasons for intensifying the disease’ prognosis. In this study we aimed to investigate the changes of tissue factor (TF) and other coagulation parameters in cases who will have an operation of total knee arthroplasty surgery. Methots. In our current work, control group (n=20) and patient group (n=20) were examined in comparison according to the TF and other extrinsic coagulation factors. TF levels of plasma and synovia were determined by ELISA method whereas other coagulation factors and protrombin time are evaluated with commercial kits, fibrinogen is determined by automatic coagulometer and C-reactive protein nephelometric method. Results. TF levels of the patient group increased significantly both in synovia and plasma (p<0.001 and p<0.05). Besides, other extrinsic system factors increased in cases’ synovia in relation to the control group. Conclusion. The high amount of fibrin, which we believe is related to increased TF in synovia and plasma, may trigger coagulation and inflammation in the patient group and may negatively affect the disease process. TF increase, which was observed in this study, may accompany rises in synovia and activate coagulation which in return may result in thrombosis risk in the patient group.