Insulin autoimmune syndrome associated with the use of thiocolchicoside: A Case report

摘要

SUMMARY Insulin autoimmune syndrome (IAS) is a disease characterized by hypoglycemia and insulin antibodies without insulin usage. We report the case of a patient diagnosed with IAS that was associated with the use of thiocolchicoside. A 62-year-old female patient was admitted to our clinic with fasting and postprandial hypoglycemia symptoms. She had a fasting glucose level of 47mg/dl, and high insulin, C-peptide and insulin antibody levels were detected. However, she had no signs of hypoglycemia during a 72 hour fasting test. In addition, the patient had used thiocolchicoside for a week a month prior to the beginning of her symptoms, but she was not taking any insulin or diabetic medications. A diagnosis of IAS was made, and the patient was put on an appropriate diet. Three months following this diagnosis, the patient’s complaints have minimilized, and the insulin and C-peptide levels have decreased. Keywords: Insulin autoimmune syndrome, hypoglycemia, thiocolchicoside ?ZET ?nsülin otoimmun sendromu (IAS) hipoglisemi ve insülin kullanmaks?z?n insülin antikorlar?n?n varl??? ile karakterize nadir bir hastal?kt?r. Biz tiyokol?ikosid kullan?m?na ba?l? IAS tan?s? koydu?umuz bir vakay? sunuyoruz. 62 ya??nda bayan hasta a?l?kta ve postprandial hipoglisemi semptomlar? ile ba?vurdu. A?l?k kan ?ekeri 47mg/dl ve insülin, C peptid, insülin antikor düzeyi yüksek olarak tesbit edildi. 72 saat uzam?? a?l?k testinde hipoglisemi ya?amad?. ?ikayetlerinin ba?lamas?ndan bir ay ?ncesinde bir hafta süreyle tiyokol?ikosid kullan?m? vard?, insülin ve diyabetik ila? kullan?m? yoktu. Hastaya insülin otoimmun sendromu tan?s? kondu ve diyet tedavisi ?nerildi. Hastan?n ü? ay sonras?nda ?ikayetleri azald? insülin ve C peptid düzeyi dü?tü.