PAI-1 4G/4G gene polymorphism is associated with higher serum lipid level in Turkish population.

摘要

Aim. PAI-1 gene is a member of prothrombotic gene group. The 4G allele of the PAI-1 4G/5G polymorphism is associated with higher plasma levels of PAI-1 and increase the risk for thrombosis. Besides, there are some studies in the literature claiming an association between the 4G allele and the atherogenic lipid profile in certain populations. However, there is no detailed information about the effect of 4G on lipid levels in Turkish population. In this study, we aimed to investigate correlation between the PAI-1 4G/4G gene polymorphism and plasma lipid levels in healthy Turkish subjects. Method. Medical genetic department and hospital database were used in this retrospective study. Over 55 years old subjects were excluded. None of these subjects was receiving any type of medication. Fifty subjects (Group 4G) which had isolated 4G/4G homozygote PAI-1 gene polymorphism and 59 subjects (Group 5G) which had normal (5G/5G) PAI-1 gene variant were included in the study. Body mass index (BMI), age, sex, blood pressure (BP), high-density lipid levels (HDL), low-density lipid levels (LDL), triglyceride and cholesterol levels were investigated in each group. Obtained data were evaluated statistically. Results. The groups were similar about age, sex, BMI and BP. The difference was not significant between each groups, were compared for HDL. However, the levels of LDL (p=0.01), triglyceride (p=0.001) and cholesterol (p=0.02) were significantly higher in Group 4G. Conclusions. PAI-1 is a characteristic biological example of how complicated and unpredictable could be the influence of the same enzyme on different tissues or organs. Our findings suggest that the 4G/4G polymorphism of the PAI-1 gene might be associated with higher serum of LDL and triglyceride in healthy Turkish population. Therefore, evaluation of the PAI-1 gene in hyperlipidemic population will help clarify etiology and prognosis of the disease.