Dysregulation of miRNA and its potential therapeutic application in schizophrenia

摘要

Summary Although it is generally believed that genetic and developmental factors play critical roles in pathogenesis of schizophrenia, however, the precise etiological mechanism of schizophrenia remains largely unknown. Over past decades, mi RNA s have emerged as an essential post‐transcriptional regulator in gene expression regulation. The importance of mi RNA in brain development and neuroplasticity has been well‐established. Abnormal expression and dysfunction of mi RNA s are known to involve in the pathophysiology of many neuropsychiatric diseases including schizophrenia. In this review, we summarized the recent findings in the schizophrenia‐associated dysregulation of mi RNA and functional roles in the development and pathogenesis of schizophrenia. We also discussed the potential therapeutic implications of mi RNA regulation in the illness.