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Association between Sex, Age, Insulin Regimens and Glycemic Control in Children and Adolescents with Type 1 Diabetes

机译:1型糖尿病儿童和青少年的性别,年龄,胰岛素治疗方案与血糖控制之间的关联

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We examined the association between sex, age, insulin regimens and glycemic control in 133 Japanese children and adolescents, 42 males and 61 females aged 16.8 ± 7.0 yr, with type 1 diabetes mellitus (T1DM). The patients were divided into 5 age groups and were also classified according to the insulin regimen. The annual median HbA1c level in males (7.3 ± 0.2%) was similar to that in females (7.2 ± 0.2%). In regard to the age of the patients, the median HbA1c levels in patients aged 15-19 yr (7.9 ± 0.4%) was significantly higher than those aged 5-9 yr (7.2 ± 0.1%) and those aged 20≤ yr (6.6 ± 0.4%, p<0.05, respectively). On the other hand, there were no significant relationships between the HbA1c values and the insulin regimens. In conclusion, difficulty in management of diabetes due to emotional issues and endocrinological factors during adolescence may play a possible role in the deterioration of diabetes control. On the other hand, the insulin regimen does not seem to have a major impact on the metabolic outcome in young people with T1DM.
机译:我们检查了133名日本儿童和青少年,16.8±7.0岁的42名男性和61名女性与1型糖尿病(T1DM)的性别,年龄,胰岛素治疗与血糖控制之间的关系。将患者分为5个年龄组,并根据胰岛素治疗方案进行分类。男性的HbA1c年平均水平(7.3±0.2 %)与女性(7.2±0.2%)相似。就患者年龄而言,15-19岁患者的HbA1c水平中位数(7.9±0.4 %)显着高于5-9岁患者(7.2±0.1 %)和20岁患者≤yr(分别为6.6±0.4 %,p <0.05)。另一方面,HbA1c值与胰岛素治疗方案之间没有显着关系。总之,青春期情绪问题和内分泌因素导致的糖尿病管理困难可能在控制糖尿病方面起着重要作用。另一方面,胰岛素治疗似乎对T1DM年轻人的代谢结果没有重大影响。

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