Gonadal failure among female patients after hematopoietic stem celltransplantation for non-malignant diseases

摘要

Hematopoietic stem cell transplantation (HSCT) is crucial for treating pediatric patientswith blood- or bone marrow-related malignant diseases; due to technical advances in HSCT,the number of survivors who have undergone HSCT has been increasing rapidly (1,2,3). Since HSCT involves a conditioning therapy withintensive chemotherapy and/or radiation, many survivors have been revealed to show long-termconsequences resulting from the therapy (3, 4). These consequences seriously affect the quality oflife of the patients, and are considered one of the major medical concerns of the therapy.Thus, pediatric malignant disease patients have been called childhood cancer survivors(CCS), and regular examinations of the physical and psychological conditions of thesepatients are recommended (5).