Background: The purpose of this study was to examine retinal recovery processes to-pographically by the application of three flash sequences with specific interstimulus intervals.Methods: Twelve healthy subjects underwent multifocal electroretinography with a light-emitting diode stimulator. Every flash sequence consisted of three flashes with?25?msec between the first and the second flash and?35?msec between the second and the third flash. The interval between the third and the first flash of the next step was?85?msec. The interstimulus interval-dependent amplitude reductions of the multifocal electroretinographic response for these three intervals yielded three data points that were used to determine the complete curve of the recovery kinetics.Results: Amplitude reductions were higher with shorter interstimulus intervals. The mean half-life periods of the recovery kinetics for the different concentric rings and all subjects were: ring?1,?29.3±5.9?msec; ring?2,?24.2±6.4?msec; ring?3,?23±4.1?msec; ring?4,?23.1±4.6?msec; and ring?5,?22.3±4.4?msec. The differences between the first and all other rings were statistically significant (P<0.05).Conclusion: The kinetics of the amplitude recovery after short interstimulus intervals showed a spatial distribution, with faster recovery toward the macular periphery.
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