Bis-pyrimidine acetamides: design, synthesis and biological evaluation

摘要

Background In the past few years, increased resistance of microorganisms towards antimicrobial agents become a serious health problem, so there is a need for the discovery of new antimicrobial agents. On the other hand, bis-pyrimidines possess various types of biological activity. In view of this, in the present study we have designed and synthesized a new series of bis-pyrimidine acetamides by Claisen鈥揝chmidt condensation and screened for its in vitro antimicrobial and anticancer activities.