Neuroinvasive Cryptococcosis in an Immunocompetent Patient with a Negative Spinal FluidCryptococcusAntigen

摘要

58-year-old man presented with headache, nausea, vomiting, and gait disturbance. Brain MRI showed meningeal enhancement and herniation. SerumCryptococcusantigen was positive but spinal fluid antigen and cultures were negative. A cerebellar biopsy revealed nonencapsulatedCryptococcus. He completed antifungal therapy. SerumCryptococcusantigen titer decreased. He had a full neurological recovery.