Two New Antifungal Cyclic Lipopeptides from Bacillus marinus B-9987

摘要

Two new cyclic lipopeptides maribasins A ( 1 ) and B ( 2 ) were isolated from the fermentation broth of the marine microorganism Bacillus marinus B-9987 isolated from Suaeda salsa in Bohai coastline of P. R. China. Both structures were established to be cyclo ( D -Pro- L -Gln- L -Asn- L -Ser- D -Asn1- D -Tyr- D -Asn2- D -β-aminoisopentadecanoic acid) ( 1 ) and cyclo ( D -Pro- L -Gln- L -Asn- L -Ser- D -Asn1- D -Tyr- D -Asn2- D -β-aminoanteisopentadecanoic acid) ( 2 ) by spectroscopic analysis and exhibited broad-spectrum activity against phytopathogens by the antifungal bioassay.