Practical Synthesis of Pachastrissamine (Jaspine B), 2- epi -Pachastrissamine, and the 2- epi -Pyrrolidine Analogue

摘要

The practical syntheses of pachastrissamine (jaspine B), 2- epi -pachastrissamine, and the 2-epimer of the pyrrolidine analogue were accomplished via the stereoselective reduction of an allylketone derived from commercially available diethyl D-tartrate and the cross-metathesis of an allyltetrahydrofuran or allypyrrolidine with 1-tridecene as key steps.