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NEW PROCESS FOR THE SYNTHESIS OF 1,3,4,5- TETRAHYDRO- 2H -3- BENZAZEPIN -2- ONE COMPOUNDS AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID
NEW PROCESS FOR THE SYNTHESIS OF 1,3,4,5- TETRAHYDRO- 2H -3- BENZAZEPIN -2- ONE COMPOUNDS AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID
wherein R1 and R2, which may be the same or different, each represent a linear or branched (C1-C8)alkoxy group or form, together with the carbon atom carrying them, a 1,3-dioxane, 1,3-dioxolane or 1,3-dioxepane ring. Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.
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