A procedure for the synthesis of compounds of the 1,3,4,5 - tetrahydro - 2H - 3 - benzazepin - 2 - One, and its application to the synthesis of Ivabradine and its Addition salts with a pharmaceutically acceptable acid

摘要

Formula compound (2),R1 and R2, the same or different, each represent a linear or branched type of alcox c1-8 group, or formed together with carbon atoms, consisting of 1,3-diazo, 1,3-diazo or 1,3-diazo. ILO Convention No. 1: procedures for the synthesis of formula compounds (1),Among them, the same or different R1 and R2 represent a linear or branched group of alcox c1-8, or formed together with carbon atoms, consisting of 1,3-diazo, 1,3-diazo or 1,3-diazo, or 1,3-diazo ring, characterized by testing formula compound (2),In this case, R1 and R2 are catalytically hydrogenated, as defined above, in a non oxidizing solvent, then filtered and mixed to obtain a formula compound (1). Requirement No. 11: procedure for the synthesis of salts and hydrates acceptable to ivabradina and its drugs, which is characterized in that according to the procedure of requirement No. 1, the formula compound (2) becomes the intermediate (1) of the formula, and then the compound formula intermediate (1) becomes the intermediate (1) of the formula EVA ladina