Relationship between serum osteocalcin level and carotid intima-media thickness in a metabolically healthy Chinese population

摘要

Background The relationship between osteocalcin and atherosclerosis remains unclear. This might be due to different degrees of confounding from factors that are associated with serum osteocalcin level, such as metabolic-related variables. This study aimed to investigate the relationship between serum osteocalcin level and carotid intima-media thickness (C-IMT) in a metabolically healthy population. Methods A total of 476 subjects with normal values for weight, glucose tolerance, blood pressure, and lipids (age range, 20–75 years; 155 men, 201 premenopausal women, 120 postmenopausal women) from the Shanghai Obesity Study were recruited for this cross-sectional study. Subjects with a history of cardiovascular disease or carotid plaque were excluded. C-IMT was measured by ultrasonography. Serum osteocalcin level was assessed by an electrochemiluminescence immunoassay. Results Median C-IMT in the entire study population was 0.55?mm with an interquartile range of 0.50–0.60?mm. C-IMT in premenopausal women was significantly lower than that in men and postmenopausal women (all P?P?P? Conclusions Serum osteocalcin level was not independently associated with C-IMT in a metabolically healthy Chinese population.