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首页> 外文期刊>Cardiovascular Diabetology >Relationship between polyunsaturated fatty acid composition in serum phospholipids, systemic low-grade inflammation, and glycemic control in patients with type 2 diabetes and atherosclerotic cardiovascular disease
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Relationship between polyunsaturated fatty acid composition in serum phospholipids, systemic low-grade inflammation, and glycemic control in patients with type 2 diabetes and atherosclerotic cardiovascular disease

机译:2型糖尿病和动脉粥样硬化性心血管疾病患者血清磷脂中多不饱和脂肪酸成分与全身低度炎症和血糖控制之间的关系

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There are inconsistent data about the role of serum phospholipid fatty acid composition in patients with type 2 diabetes (T2DM) and atherosclerotic cardiovascular disease (ASCVD). The aim of the study was to investigate the relationship between serum phospholipid fatty acid composition, systemic low-grade inflammation, and glycemic control in high-risk T2DM patients. Seventy-four patients (26% women, mean age 65.6?±?6.8?years) with T2DM (median diabetes duration 10?years) and documented ASCVD (74 with coronary artery disease, 26 with peripheral arterial disease) were enrolled in the study. Baseline HbA1c was estimated using turbidimetric inhibition immunoassay. According to the median value of HbA1c the patients were grouped into those with HbA1c?
机译:关于血清磷脂脂肪酸组成在2型糖尿病(T2DM)和动脉粥样硬化性心血管疾病(ASCVD)患者中的作用的数据不一致。该研究的目的是研究高危T2DM患者的血清磷脂脂肪酸组成,全身性轻度炎症和血糖控制之间的关系。本研究纳入了74例T2DM(中位糖尿病持续时间为10多年)和T2DM(中位糖尿病持续时间为10多年)的患者(26%的女性,平均年龄为65.6?±6.8?岁),并记录了ASCVD(74例伴有冠状动脉疾病,26例伴有外周动脉疾病)。 。使用比浊抑制免疫分析法估算基线HbA1c。根据HbA1c的中位数,将患者分为HbA1c 7.0%(<?53?mmol / mol)(n?=?38)和HbA1c≥≥7.0%(≥53%)的患者。 (mmol / mol)(n = 36)。用气相色谱法测定血清磷脂脂肪酸。 HbA1c≥≥7.0%的患者与HbA1c≤≥7.0%的患者血清磷脂中饱和和单不饱和脂肪酸组成相似,但亚油酸(LA)浓度较高,n-6 / n-较高3多不饱和脂肪酸(PUFA)比率以及二十碳五烯酸(EPA),总n-3 PUFA含量较低以及EPA /花生四烯酸比率较低。我们发现,LA(r≥0.2,p≥0.03)和n-6 / n-3 PUFA比(r≥0.28;p≥0.02)与HbA1c正相关。多元逻辑回归分析显示,n-6 / n-3 PUFA比率,hsCRP和T2DM持续时间是T2DM和ASCVD患者血糖控制较差的独立预测因素。这项研究表明,高危T2DM ASCVD患者的血糖控制与不良的血清磷脂n-6 / n-3 PUFA比和更大的全身性炎症显着相关。

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