Prognostic values of baseline, interim and end-of therapy 18 F-FDG PET/CT in patients with follicular lymphoma

摘要

Purpose: In the present study, we aimed to investigate the role of baseline, interim and end-of treatment positron emission tomography/computed tomography (PET/CT) in assessing the prognosis of follicular lymphoma (FL). Methods: A total of 84 FL patients were retrospectively analyzed in this study. Baseline (n=59), interim (n=24, after 2–4 cycles) and end-of treatment (n=43) PET/CT images were re-evaluated, and baseline maximum standardized uptake value (SUVsubmax/sub), total metabolic tumor volume (tMTV) and total lesion glycolysis (TLG) were recorded. Interim (I-PET) and end-of treatment (E-PET) PET/CT responses were interpreted by Deauville five-point scale (D-5PS) and International Harmonization Project criteria (IHP). Survival curves were calculated by Kaplan-Meier curves, and differences between groups were compared by log-rank test. Results: The 2-year progression-free survival (PFS) of the high- and low-TLG groups was 57.14% and 95.56%, respectively ( p =0.0001). The 2-year overall survival (OS) of the high- and low-TLG groups was 62.50% and 100%, respectively ( p 0.0001). Multivariate analysis showed that TLG was an independent prognostic factor for PFS ( p =0.001, HR=6.577, 95% CI=2.167–19.960) and OS ( p =0.030, HR=19.291, 95% CI =2.689–137.947). Besides, Eastern Cooperative Oncology Group (ECOG) was the independent prognostic factor for OS (HR=8.924, 95% CI=1.273–62.559, p =0.028). Interim PET results based on D-5PS or IHP criteria were not significantly correlated with PFS (all p 0.05). However, E-PET results using D-5PS and IHP criteria were statistically significant ( p =0.0001 and p =0.006). The D-5PS showed stronger prognostic value compared with IHP criteria. The optimal cutoff value of ΔSUVsubmax/sub% was 66.95% according to I-PET and 68.97% according to E-PET. However, only the ΔSUVsubmax/sub% from the baseline to the end-of therapy yielded statistically significant results in the prediction of PFS ( p =0.0002). Conclusion: Our findings indicated that the baseline TLG and E-PET results were significantly associated with prognosis in patients with FL.