Neuropeptide Y Gene Promoter -399T/C Polymorphism Increases Risk of Ischemic Stroke

摘要

Background: Several genetic factors underlying ischemic stroke have been identified. Variants of Neuropeptide Y (NPY), whose product plays diverse roles in modulating physiological functions, have been associated with an increased risk of ischemic stroke in South Korean individuals. Aims: We explored the association between a polymorphism in the NPY gene promoter at position -399 and the risk of ischemic stroke in Han Chinese. Study Design: Case-control study. Methods: The polymorphism -399T/C in the promoter of NPY was analysed in 500 patients with ischemic stroke and 500 healthy individuals by amplification and sequencing of this region. Non-conditional logistic regression was used to analyse association between genotypes and the risk of ischemic stroke. Results: Genotype and allele frequencies differed significantly between the ischemic stroke and control groups (P0.05). Conclusion: The -399T/C polymorphism of the NPY gene is associated with ischemic stroke in Han Chinese individuals, and the CC genotype may be a risk factor for ischemic stroke. Turkish Ba?l?k: N?ropeptid Y Gen Promotoru -399T/C Polimorfizmi ?skemik ?nme Riskini Art?rmaktad?r Anahtar Kelimeler: ?skemik inme, N?ropeptid Y, Gen polimorfizmleri Arka Plan: ?skemik inmenin alt?nda yatan bir?ok genetik fakt?r tan?mlanm??t?r. ürünleri fizyolojik fonksiyonlar? modüle etmede ?e?itli roller oynayan N?ropeptid Y (NPY) varyantlar? Güney Koreli ki?ilerde iskemik inme riskinde art?? ile ili?kilendirilmektedir. Ama?: Han ?inlilerinde NPY gen promotoru -399 pozisyonundaki polimorfizm ile iskemik inme riski aras?ndaki ili?kiyi ara?t?rd?k. ?al??ma Tasar?m?: Olgu kontrol ?al??mas?. Y?ntemler: ?skemik inmeli 500 hastada ve 500 sa?l?kl? ki?ide NPY promotorundaki -399T/C polimorfizmi bu b?lgenin amplifikasyon ve sekanslamas? ile analiz edildi. Genotipler ile iskemik inme riski aras?ndaki ili?kiyi analiz etmek i?in ko?ulsuz lojistik regresyon kullan?ld?. Bulgular: ?skemik inme ve kontrol gruplar? aras?nda genotip ve allel frekanslar? anlaml? ?ekilde farkl?yd? (P0.05). Sonu?lar: Han ?inlilerinde NPY geninin -399T/C polimorfizmi iskemik inme ile ili?kilidir ve CC genotipi iskemik inme i?in bir risk fakt?rü olabilir.