Comparsion of side effect profile of melperone and haloperidol: a double bline study

摘要

Because of nearly 90 percent of adverse effect rate of classical neuroleptic drugs, in new group antipsychotic drugs, low rate extrapyramidal side effects are indicated besides high rate neuroleptic efficiency. There are some studies suggesting that melperone is an atypical neuroleptic drug. In this study, it was aimed to compare the side effects of melperone and haloperidol. Among the patients received acute and exacarbated schizophrenia diagnosis, 18 patients were given haloperidol (15 mg/gün) and 20 patients given melperone (375 m g/gün) within 42 days. Two groups compared the side effects profile in double-blind fashion. The side effect profiles were evaluated with the UKU side effect rating scale, MMSE, complete blood count, routine biochemistry tests, PRL, cortisol, ECG and EEG-mapping. In the LJKU side effects rating scale; psychic side effects were similar in two groups, but asthenia, sleepiness/sedation, increased duration of sleep and emotional indifference were more severe in patients w7ho given haloperidol (p<0.05). Neurological side effects were similar in two groups, but only hypokinesia/akinesia subscale wras occured more in patients who given haloperidol (p<0.05). Except the increase of salivation, autonomic side effects were more common and severe in melperone group (p<0.05). Statistically significant increase in PRL and cortisol has been determined in melperone group, but in the haloperidol group, only PRL has increased significantly (p<0.05). There is no significant difference on ECG and EEG monitoring.