Antitumor Effect of Coriolus versicolor Queil Alcoholic Extract

摘要

Coriolus versicolor Queil is a mushroom traditionally used in Asian herbalremedies. In the present study, C. versicolor alcoholic extract was tested on Ehrlich Ascitic Carcinoma(EAC) model. The experiment was carried out on 30 white Swiss male mice, 106 EAC cells / animali.p. Animals were divided in three equal groups; first group (C. versicolor + EAC group) received inthe day 1, 4 and 7 - 50 ml sol./kg b.w. C. versicolor 1:10. The second group was the EAC group andthe last group (Doxorubicin + EAC group) received i.p. Doxorubicin cloride 2.5 mg/ kg b.w. in day 6of experiment. Other 30 animals were subject of administration of mushroom extract, control andDoxorubicine chloride alone in the same doses, at the same time. C. versicolor alcoholic extractprovides the significant increase in white blood cells, and the platelets as compared to control. Thesurvival rate was also higher in treated groups, and the extract was able to prevent in a significantmanner the increasing in the body weight do to accumulation of the ascitic fluid. C. versicolorreduced, also, the ascitic volume and cellular concentration of the ascitic fluid, but not statisticallysignificant. C. versicolor alcoholic extract revealed a considerable antitumoral activity, along with thesafety profile; therefore C. versicolor is recommended for further studies, in other to find newremedies in complementary cancer therapy.