Pharmacovigilance and tuberculosis: applying the lessons of thioacetazone

摘要

Following its introduction in the late 1940s, thioacetazone was widely-used as an anti-tuberculosis medicine in the following decades. 1 Reports of cutane- ous hypersensitivity reactions related to its use emerged in the literature soon after its introduction and by the early 1970s the association between the medi- cine and the adverse drug reaction was well established. 2 Despite the increased recognition of this risk, thioacetazone remained in use mainly in low-income countries becaus e of its low cost