Trend of developing resistance among isolates of Acinetobacter spp.; Threat of hospital acquired infection

摘要

Aim: Acinetobacter sp. is a Gm-ve bacteria which is a major cause of serious infections. Today it has emerged as multidrug resistant organism. The aim of current study was to evaluate the trend of sensitivity/resistance pattern of Acinetobacter spp. against broad spectrum antibiotics. M ethod: Standard Kirby bauer Disc Diffusion method was adopted to conduct the study according to the CLSI 2013 Standards. Total 52 isolates were collected from different sites of inpatients admitted to renowned tertiary care hospital from Feb 2014-March 2014 and sensitivity/resistance pattern was observed against 08 broad spectrum antibiotics of different classes. Result: It is observed that 61.5% of all samples were obtained from male patients while, the mean range of age group among both the gender frequently found infected was 51-75 yrs. The highest percentage of isolate was obtained from tracheal aspirate (55.76%) of both the genders. Both Colistin and Polymixin were found to be most effective against 98% isolates each while Imipenem was the least effective broad spectrum antibiotic. Thus, the isolates were highly resistant to 05 antibiotics traditionally used to treat infections caused by Acinetobacter spp. Surprisingly, more than 32% of isolates showed Intermediate sensitivity to Fosfomycin . Conclusion: Due to emerging trend of developing resistance among Acinetobacter spp. and spread of hospital acquired infections, there is a serious need to take necessary steps by hospital officials to ensure cleanliness. Patients should also be educated about the proper use of antibiotics.