Protective Role of Water Extract of Unripe Pulp of Carica papaya (Fruit) Against a Potassium Bromate Induced Tissue Damage in Wistar Rats

摘要

The aim of this study was to evaluate the protective role of water extract of unripe pulp of Carica papya against potassium bromate induced tissue damage in wistar rats. Twenty (20) rats were grouped into five groups of four rats each. Group A (base-line control), was administered 1 mL of 0.25 M sucrose solution. Group B was not pretreated with the extract but induced with KBrO₃. Group C and D were pretreated with 250 mg/kg and 500 mg/kg body weight of the extract respectively. Tissue damage was induced in Group B, C, and D by oral administration of 60mg/kg body weight of potassium bromate. The rats were sacrificed eight hours after KBrO₃ induction and, the liver, spleen, brain, kidney, heart and stomach were collected. The organ to body weight ratio, total protein, amino acid and malondialdelhyde level were evaluated in the tissue. The result showed a significant increase (pCarica papaya (fruit) has a protective role against tissue damage induced by KBrO₃.